Year: 2023 | Month: August | Volume 13 | Issue 4
In-silico Designing and Testing of Multiprotein Vaccine Construct Against Cow Milk Allergy
Nidhi Sukhija
Kanaka K.K.
Komal Jaglan
Chethan Raj
Sona Sukhija and Vidhyasagar
DOI:10.30954/2277-940X.04.2023.5
Abstract:
Cow’s milk allergy is a common diagnosis in infants and children, and it manifests as a hypersensitivity reaction to the allergenic
proteins in cow milk. Cow milk contains about 20 distinct protein components. The primary allergens are casein protein (alpha-s1-, alpha-s2-, beta-, and kappa-casein) and whey protein (alpha-lactalbumin and beta-lactoglobulin). There are several allergy treatments available, but they are just temporary. Developing a vaccine against milk allergy may appear utopian. Epitopes were found and exploited to build a multiprotein vaccine in this immunoinformatics study. Immunoinformatics techniques were used to predict T- and B-cell epitopes. Adjuvants were used to boost the vaccine’s antigenicity. The created vaccine design was shown to be soluble, antigenic, non-allergenic, and non-toxic.
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